United States securities and exchange commission logo

                        October 3, 2022

       Brandi Roberts
       Chief Financial Officer
       Longboard Pharmaceuticals, Inc.
       4275 Executive Square, Suite 950
       La Jolla, California 92037

                                                        Re: Longboard
Pharmaceuticals, Inc.
Statement on Form S-3
                                                            Filed September 30,
                                                            File No. 333-267674

       Dear Brandi Roberts:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jimmy
McNamara at 202-551-7439 with any questions.


                        Division of Corporation Finance

                        Office of Life Sciences
       cc:                                              Alexa Ekman